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KMID : 0648420110160010013
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Journal of Korean Society of Pediatric Endocrinology
2011 Volume.16 No. 1 p.13 ~ p.19
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Analysis of Cytokines in Sera from Type 1 Diabetic Patients at Diagnosis
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Yoon In-Suk
Shin Choong-Ho
Yang Sei-Won
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Abstract
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Purpose: Diverse cytokines influence the pathogenesis of type 1 diabetes mellitus (T1DM) in different ways. We
studied the profile of cytokines in sera from type 1 diabetic patients at diagnosis.
Methods: Serum levels of 11 cytokines (IL-1α, IL-1β, IL-1Ra, IL-2, IL-4, IL-6, IL-10, IL-12 (p70), INF-γ, and TNF-α)
from 38 newly-diagnosed T1DM patents and 39 healthy controls were measured, using multiplex immunoanalytic
xMAP.
Results: Patients showed significantly higher levels of IL-1β (P ? 0.01), IL-10 (P ? 0.01), and TNF-α (P = 0.019),
than the healthy controls. In 12 of 35 patients, the insulin autoantibody (IAA) was positive (34%) and the level
of IAA was correlated with IL-10 (r = 0.454, P = 0.006), and TNF-α (r = 0.368, P = 0.030).
Conclusion: These results suggest that IL-1β, TNF-α, and IL-10 play a role in the pathogenesis of T1DM, and
the level of the IAA is correlated with IL-10 and TNF-α.
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KEYWORD
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Diabetes mellitus, type 1, Cytokines, Interleukin-1beta, Tumor necrosis factor-alpha, Interleukin-10, Islet cell antibody
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